Mouth and teethDrug

Antibody against USAG-1 regrows teeth in mice

Phase 1 trial

The furthest trial that has started is a Phase 1 trial.

The status rests on these records

Status set 11 Nov 2026.

Latest record 3 Oct 2025

Researchers at Kyoto University and the University of Fukui reported that one dose of an antibody blocking the protein USAG-1 grew a whole new tooth in mice with congenital tooth agenesis, with similar results in ferrets. The paper appeared in Science Advances in February 2021.

Intervention
Anti-USAG-1 antibody (also known as TRG035, TRG-035, USAG-1 neutralizing antibody)
Claimed for
congenital tooth agenesis
First reported
31 Mar 2021
Evidence then
Animal study

Recorded

  • Promised
  • News report
  • Trial registry record
  • Basis of status

No dated promise on record.

YearRecorded
2021
2022 to 2023No record
2024
  • 8 Oct

    Phase 1 trial jRCT2051240154 registered: a single dose of TRG035 in healthy adults.

    The status rests on this record.

    Date taken from: registry date of registration.

    jRCT, jRCT2051240154
2025
  • 3 Oct

    Trial jRCT2051240154 shown as complete in the registry.

    The status rests on this record.

    Date taken from: registry last modified; the registry shows the trial as complete and gives no completion date.

    jRCT, jRCT2051240154
2026this yearNo record yet

Promised with no date

  • tests in other animals such as pigs and dogs nextKyoto Universitykyoto-u.ac.jp 31 Mar 2021

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“New drug to regenerate lost teeth” (Kyoto University). First reported 2021. Status now Phase 1 trial. Checked Nov 2026. Not medical advice.

Antibody against USAG-1 regrows teeth in mice. First reported Mar 2021. Status when checked in Nov 2026: Phase 1 trial. Not medical advice. https://whatcameofit.com/tooth-regrowth-usag1

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