{
  "licence": "Creative Commons Attribution 4.0 International (CC BY 4.0)",
  "credit": "What came of it? (https://whatcameofit.com), licensed under Creative Commons Attribution 4.0 International (CC BY 4.0), https://creativecommons.org/licenses/by/4.0/. Indicate if changes were made.",
  "sources": [
    {
      "name": "ClinicalTrials.gov",
      "url": "https://clinicaltrials.gov/"
    },
    {
      "name": "Europe PMC",
      "url": "https://europepmc.org/"
    },
    {
      "name": "Crossref",
      "url": "https://www.crossref.org/"
    },
    {
      "name": "jRCT",
      "url": "https://jrct.mhlw.go.jp/"
    }
  ],
  "method": "https://whatcameofit.com/how-it-works",
  "generated_at": "2026-11-12T20:51:46.490510Z",
  "last_checked_at": "2026-11-11T16:48:25.175814Z",
  "preview": false,
  "claims": [
    {
      "slug": "tooth-regrowth-usag1",
      "headline": "Antibody against USAG-1 regrows teeth in mice",
      "summary": "Researchers at Kyoto University and the University of Fukui reported that one dose of an antibody blocking the protein USAG-1 grew a whole new tooth in mice with congenital tooth agenesis, with similar results in ferrets. The paper appeared in Science Advances in February 2021.",
      "vertical": "mouth-and-teeth",
      "intervention": {
        "name": "Anti-USAG-1 antibody",
        "synonyms": [
          "TRG035",
          "TRG-035",
          "USAG-1 neutralizing antibody"
        ]
      },
      "indication": "congenital tooth agenesis",
      "first_reported_date": "2021-03-31",
      "evidence_stage": "animal",
      "status": {
        "code": "phase_1",
        "overlay_years": null,
        "updated_at": "2026-11-11T16:48:25.175814Z",
        "explained_by": [
          5,
          6
        ]
      },
      "articles": [
        {
          "outlet": "Kyoto University",
          "title": "New drug to regenerate lost teeth",
          "published_date": "2021-03-31",
          "url": "https://www.kyoto-u.ac.jp/en/research-news/2021-03-31",
          "archive_url": null
        }
      ],
      "promises": [
        {
          "description": "tests in other animals such as pigs and dogs next",
          "parsed_date": null,
          "article_url": "https://www.kyoto-u.ac.jp/en/research-news/2021-03-31"
        }
      ],
      "events": [
        {
          "id": 5,
          "type": "trial_registered",
          "event_date": "2024-10-08",
          "date_basis": "registry date of registration",
          "summary": "Phase 1 trial jRCT2051240154 registered: a single dose of TRG035 in healthy adults.",
          "source_name": "jRCT",
          "source_url": "https://jrct.mhlw.go.jp/en-latest-detail/jRCT2051240154",
          "trial_id": "jRCT2051240154",
          "trial_phases": [
            "phase_1"
          ],
          "trial_state": null,
          "regulatory_outcome": null
        },
        {
          "id": 6,
          "type": "trial_status_change",
          "event_date": "2025-10-03",
          "date_basis": "registry last modified; the registry shows the trial as complete and gives no completion date",
          "summary": "Trial jRCT2051240154 shown as complete in the registry.",
          "source_name": "jRCT",
          "source_url": "https://jrct.mhlw.go.jp/en-latest-detail/jRCT2051240154",
          "trial_id": "jRCT2051240154",
          "trial_phases": [
            "phase_1"
          ],
          "trial_state": "completed",
          "regulatory_outcome": null
        }
      ],
      "checked_by_person": true
    }
  ]
}